University teaching professionalization is a necessity in modern society. The scientific and technical revolution that has been taking place in the world demands a different preparation for teachers. Modern universities need professors adapted to these new times. The professionalization of teachers today constitutes a challenge as well as a social commitment.

Background: Up to now COVID-19 treatment is a matter of great debate. Several trials and observational studies have brought conflicting results regarding the efficacy of some repurposed drugs suggested treating COVID-19, stressing the need for further research. Objective: This study aimed to add to the existing literature, some evidence on the efficacy and safety of hydroxychloroquine (HCQ) and azithromycin (AZ) as suggested drugs for COVID-19 treatment. Materials and Methods: This observational study reports the experience of conventional treatment (CT) combining HCQ plus AZ applied in the Democratic Republic of Congo. We compared epidemiological and clinical data between 1,100 (89%) subjects submitted to the CT and 135 (11%) who did not receive the CT. Survival analyses including Kaplan-Meier and Cox regression were used to determine the clinical progress at day 10 and the survival likelihood at day 15, from the treatment initiation date. Results: Clinical outcome is much better in the CT group on D10 than in the comparison group (p=0.001). The adverse effects reported are minor and equivalent in both groups (3% vs 3%). Conclusion: This preliminary observational study suggests a beneficial and safe effect of conventional treatment in our country and justifies the continuation of this therapeutic protocol at this time. However, larger analytical studies with more robust evaluation criteria are needed to strengthen the power of observations.

Teenage pregnancy is a global health problem. The beginning of sexual life at an earlier age has an impact on the increase in sexually transmitted diseases, unwanted pregnancies, and the number of single mothers. Each year approximately 2 million adolescents under the age of 15 become pregnant and an estimated 16 million girls between the ages of 15 and 19 give birth, 95% of these births occur in developing countries. Adolescent births as a percentage of all births range from around 2% in China to 18% in Latin America and the Caribbean. The global rate of adolescent pregnancy is estimated at 46 births for every 1,000 girls and of the same Thus, the rate for Latin America corresponds to 66.5 births per 1,000 girls between the ages of 15 and 19, ranking second worldwide, only surpassed by Sub-Saharan Africa. Furthermore, complications during pregnancy and childbirth are the second leading cause of death among women 15-19 years of age worldwide.

The prostasome is the first described exosome and constitutes the third communication system between cells mediating messages besides gap junctions and soluble compounds such as hormones. Exosomes are nanometer vesicles surrounded by a lipid bilayered membrane and released by most cell types including malignant cells. The exosomal messenger system reaches distant cells even on the other side of the blood brain barrier. In this way they are able to interact with their target cells for delivery of their cargo. We here describe prostasomal properties in more detail thus exemplifying common exosomal characteristics. Myocardial derived exosomes (cardiosomes), are also described in order to highlight other common biological functions including damaged tissue, i.e. tissue repair. Abnormal tissue such as malignant progression can be driven by cancer cell derived exosomes, believed mainly to be mediated by different forms of short RNAs exerting their action through specific signaling pathways related to metastases, therapeutic resistance and immunosuppression.

Background A retrospective analysis of the 40-year absence of maternal mortality in critical obstetric, in different countries, was due to the timely decentralization of macro-circulation through the recruitment of the microcirculatory-mitochondrial, in the space: capillaries - cell - mitochondria; detoxification; and adequate analgesia. Recruitment of microcirculatory – mitochondrial reduces, microcirculatory-mitochondrial distress syndrome (MMDs) and syndrome of multi-organ dysfunction (MODs), by decentralizing macro-circulation, as a result, systemic perfusion pressure (SPP), is stabilized representing the difference between mean arterial pressure (MAP), and capillary resistance pressure, CRP, which adequately perfused the microcirculatory space of capillary ? cell ? mitochondria, thanks to adequate vascular compliance ?VP with an accelerated speed of delivery and return of blood flow, which directly leads to a decrease in tissue hypoxia marker pCO2 (AV gap ) and, respectively, decrease MMDs, MODs and many other endogenous toxic substances. Optimization of SPP by RMM at MMDs, simultaneously reducing pCO 2 (AV gap), also reduces anion gap & urinary anion gap. In cases of pulmonary/extrapulmonary damage with ? pCO2 and ? PaO2 / FiO2, ? 300 with the development of acute respiratory distress syndrome, ARDs, according to the 2012 Berlin Classification, MMDs are also aggravated at ? the pCO2 AV gap. With the development of mitochondrial collapse, MMP also needs additional support of multiple organ therapies - Multi-organ Supportive Therapy, MOST: 1) Alveolar recruitment with respiratory support in special modes of ventilation, mainly Airway Pressure Release Ventilation, APRV (P - high, T - high, P low, T - low), with permissive hypercapnia at normal pH, using inhaled pulmonary vasodilators; 2) RMM; 3) MOST - Extracorporeal life support organization - ELSO; 4) Modelling of the index of extravascular lung fluid, EVLWI; 5) Th4 - Th5 thoracic epidural block; 6) Active detoxification methods. The absence of decreasing of the pCO2 tissue hypoxia marker at the pCO2 AV gap ? 5,0 mm Hg after RMM, rejects the necrosis/apoptosis, hypo- (an)-ergic cell and proves the mitochondrial euenergetic metabolic remodeling with the elimination of the hypo-(an)-ergic mitochondria performed by lysosomal clearance (mitophagy), argues stops membrane destruction, swelling of plasma, lysosomes, mitochondria, karyorrhexis, DNA destruction and karyolysis. Thus, demonstrating eu-ergic mitochondria with the normalization of mitochondrial Ca++ uniporter - channel and mitochondrial permeability pore transition, which productively inactivate the toxic forms of oxygen, Reactive oxygen species, ROS and Reactive nitrogen species, RNS.